POS4-0688
Oligopeptide-Functionalized MOF Nanogents for Ice-Water Interface
Topic
S4. Colloids, Interfaces, and Molecular Assemblies for Functional Soft Materials
When and Where
Sep 29, 2026
08:30 - 09:30
Room 301 (Grand Ballroom)
Session Chairs
Hae Jung SON
Boseok KANG
Presenter(s)
Leeseo Kim (Gwangju Institute of Science and Technology)
Co-Author(s)
Abstract
Ice-binding proteins (IBPs) produced by cold-adapted organisms regulate ice nucleation, growth, and recrystallization, allowing survival under subzero conditions. IBPs interact selectively with ice surfaces, where ordered ice-binding residues give rise to thermal hysteresis and ice-recrystallization inhibition. Inspired by IBPs, metal-organic framework (MOF) nanoparticles can serve as rigid, periodic nanoscaffolds that spatially organize ice-binding motifs: their ordered surfaces display grafted oligopeptides whose hydrogen-bond donor groups engage the ice lattice through hydrogen bonding, while high water dispersibility, colloidal stability, and biocompatibility make them attractive cryoprotective nanoagents. Here, we prepare IBP-mimicking oligopeptide-functionalized MOF nanoparticles and tune their surface chemistry to control the hydrogen-bonding interactions and the hydrophobic-hydrophilic balance at the ice-water interface, establishing a programmable platform for low-temperature preservation.
