POS8-0581
Stimuli-Responsive Mn-doped Molecularly Imprinted Polymers for Targeted Chemodynamic Therapy
Topic
S8. Frontiers of Functional Polymers in Biology and Medicine
When and Where
Sep 30, 2026
08:30 - 09:30
Room 301 (Grand Ballroom)
Session Chairs
Heesuk KIM
Jinhye BAE
Presenter(s)
MIN SEOK KANG (HANYANG UNIVERSITY)
Co-Author(s)
Abstract
Molecularly imprinted polymers (MIPs) integrated with functional inorganic frameworks offer a powerful strategy for targeted cancer therapy, providing antibody-like specificity and multi-modal therapeutic capabilities. Herein, we developed a tumor-microenvironment (TME)-responsive biomaterial platform based on manganese (Mn)-doped biodegradable molecularly imprinted polymers (Mn-MIP) to achieve both sialic acid (SA)-targeted drug delivery and Fenton-like chemodynamic therapy (CDT).
Core Mn-doped silica nanoparticles with redox-sensitive networks were synthesized via a reverse microemulsion (RME) method. Subsequently, the nanoparticle surface underwent sequential functionalization for sialic acid (SA) immobilization, followed by surface imprinting polymerization to construct robust recognition cavities. The successful stepwise synthesis and composition of the Mn-MIP were verified via zeta (ζ) potential, TEM, and EDS analysis. Crucially, the TME-responsive nature was evaluated under biomimetic reductive conditions. Clear morphological degradation of the silica matrix triggered by elevated glutathione (GSH) levels was monitored via TEM, while ICP-OES confirmed the time-dependent release of Mn ions. Following degradation analysis, the target-binding selectivity was confirmed by boronate affinity sandwich assay (BASA), demonstrating a significantly higher affinity toward SA compared to non-imprinted controls. Furthermore, in vitro assays using MCF-7 breast cancer cells revealed remarkable targeting capability and enhanced cellular uptake compared to normal cells, subsequently inducing highly selective cytotoxicity through catalytic intracellular oxidative stress and programmatic drug release. In conclusion, the developed Mn-MIP nanoplatform demonstrated precise targeting and TME-responsive antitumor efficacy, suggesting great potential as an advanced theranostic application for targeted cancer treatment.
Core Mn-doped silica nanoparticles with redox-sensitive networks were synthesized via a reverse microemulsion (RME) method. Subsequently, the nanoparticle surface underwent sequential functionalization for sialic acid (SA) immobilization, followed by surface imprinting polymerization to construct robust recognition cavities. The successful stepwise synthesis and composition of the Mn-MIP were verified via zeta (ζ) potential, TEM, and EDS analysis. Crucially, the TME-responsive nature was evaluated under biomimetic reductive conditions. Clear morphological degradation of the silica matrix triggered by elevated glutathione (GSH) levels was monitored via TEM, while ICP-OES confirmed the time-dependent release of Mn ions. Following degradation analysis, the target-binding selectivity was confirmed by boronate affinity sandwich assay (BASA), demonstrating a significantly higher affinity toward SA compared to non-imprinted controls. Furthermore, in vitro assays using MCF-7 breast cancer cells revealed remarkable targeting capability and enhanced cellular uptake compared to normal cells, subsequently inducing highly selective cytotoxicity through catalytic intracellular oxidative stress and programmatic drug release. In conclusion, the developed Mn-MIP nanoplatform demonstrated precise targeting and TME-responsive antitumor efficacy, suggesting great potential as an advanced theranostic application for targeted cancer treatment.
