POS8-0569
Methacrylated Polysaccharide Hydrogels Crosslinked with Slide-Ring Polyrotaxane for Wound Healing Enhancement
Topic
S8. Frontiers of Functional Polymers in Biology and Medicine
When and Where
Oct 1, 2026
08:30 - 09:30
Room 301 (Grand Ballroom)
Session Chairs
Jinkee HONG
Ki Su KIM
Presenter(s)
Chaeyoung Lee (Pukyong National University)
Co-Author(s)
Abstract
Polysaccharides have attracted considerable attention as wound healing materials due to their excellent biocompatibility and moisturizing properties. However, their application is often limited by insufficient mechanical strength and rapid degradation in vivo. To address these issues, we developed polysaccharide-based hydrogels utilizing polymerizable polyrotaxane (PRMA) as a multifunctional crosslinker. Polyrotaxane was synthesized by threading β-cyclodextrin onto poly(propylene glycol) (PPG, MW = 4000), followed by end-capping with N-(triphenylmethyl)-glycine (Trt-Gly-OH) using DMT-MM as a catalyst. Methacryloyl chloride was subsequently grafted onto the threaded β-cyclodextrin to introduce polymerizable groups. In addition, sodium alginate and hyaluronic acid were modified with methacrylic anhydride to yield methacrylated alginate (AlgMA) and methacrylated hyaluronic acid (HAMA), respectively. The crosslinking of PRMA with AlgMA and HAMA is planned to produce hydrogel networks with improved mechanical properties and stability. Characterization by NMR, FT-IR, DSC and TGA confirmed the chemical structure and properties of the synthesized materials.
