POS8-0555
Composite of Bentonite and Tannic Acid as Hemostatic Biomaterials
Topic
S8. Frontiers of Functional Polymers in Biology and Medicine
When and Where
Oct 1, 2026
08:30 - 09:30
Room 301 (Grand Ballroom)
Session Chairs
Jinkee HONG
Ki Su KIM
Presenter(s)
Yeojin Kim (Pusan National University)
Co-Author(s)
Abstract
Standard wound closure modalities, such as sutures, staplers, and tapes, are widely utilized but carry inherent risks of post-operative infections and tissue complications. To address these limitations, tissue adhesives have emerged as a promising alternative with offering rapid and user-friendly application. Currently, cyanoacrylate-based adhesives are deployed for initial hemostasis in acute hemorrhage. However, cyanoacrylate possesses significant drawbacks, including risks of re-bleeding and exothermic polymerization during curing, which causes thermal damage to surrounding biological tissues.
To overcome these challenges, this study utilizes bentonite and tannic acid to develop an innovative hemostatic powder. Bentonite, a natural clay mineral composed of montmorillonite, possesses unique physicochemical attributes, including exceptional absorptive capacity and swelling properties, expanding its utility in biomedical fields. Concurrently, tannic acid, a natural polyphenol, exhibits excellent antioxidant, antimicrobial, and anti-inflammatory properties. It also acts as a natural crosslinker, enhancing the mechanical strength and biocompatibility of biomaterials. Here, bentonite and tannic acid were blended at various ratios to maximize their synergistic functional characteristics.
The developed hemostatic powder successfully combined the rapid fluid absorption of bentonite with the antimicrobial and crosslinking proficiencies of tannic acid. The resulting formulation demonstrated outstanding tissue adhesion and superior hemostatic efficacy. When applied to wounds, this powder adhesive exhibits rapid moisture uptake and facilitates immediate clot formation. Consequently, the novel biomaterial offers profound clinical advantages for controlling severe, life-threatening hemorrhages in emergency medical scenarios, establishing itself as a highly promising candidate for advanced wound care management.
To overcome these challenges, this study utilizes bentonite and tannic acid to develop an innovative hemostatic powder. Bentonite, a natural clay mineral composed of montmorillonite, possesses unique physicochemical attributes, including exceptional absorptive capacity and swelling properties, expanding its utility in biomedical fields. Concurrently, tannic acid, a natural polyphenol, exhibits excellent antioxidant, antimicrobial, and anti-inflammatory properties. It also acts as a natural crosslinker, enhancing the mechanical strength and biocompatibility of biomaterials. Here, bentonite and tannic acid were blended at various ratios to maximize their synergistic functional characteristics.
The developed hemostatic powder successfully combined the rapid fluid absorption of bentonite with the antimicrobial and crosslinking proficiencies of tannic acid. The resulting formulation demonstrated outstanding tissue adhesion and superior hemostatic efficacy. When applied to wounds, this powder adhesive exhibits rapid moisture uptake and facilitates immediate clot formation. Consequently, the novel biomaterial offers profound clinical advantages for controlling severe, life-threatening hemorrhages in emergency medical scenarios, establishing itself as a highly promising candidate for advanced wound care management.
