ORGS2-0530
Polymeric Nanoparticles as a Versatile Platform for Fluorescent Cell-Imaging and Electrochemical Sensing
Topic
GS2. Graduate Student Oral Session II: Functional Biomaterials and Cosmetic Polymer Engineering
When and Where
Sep 28, 2026
14:24 - 14:36
Room 102
Session Chairs
Chaenyung CHA
Ilkoo NOH
Jun Shik CHOI
Presenter(s)
Jio Kang (Pukyong National University)
Co-Author(s)
Abstract
In our previous work, F127-based semi-interpenetrating network (sIPN) nanoparticles with tunable surface charge were developed by incorporating phosphate- and trimethylammonium-functionalized F127. Varying their ratio controlled the surface charge density, and positively charged nanoparticles showed significantly enhanced cellular uptake in HeLa cells, demonstrating the versatility of the sIPN platform. Building on this platformn, the sIPN was repurposed as a redox-active material for glucose sensing. Screen-printed carbon electrodes (SPEs) were electrochemically activated and modified with Fc sIPNs, after which a spin-coated polyacrylamide (PAAm) layer was introduced to improve nanoparticle retention and mediator stability, followed by glucose oxidase (GOx) immobilization. Cyclic voltammetry confirmed reversible ferrocene redox through each step, and chronoamperometry showed a concentration-dependent glucose response, demonstrating their use as both nanocarriers and electroactive mediator platforms for glucose biosensing. These findings demonstrate that F127-based sIPN nanoparticles can serve as both nanocarriers and electroactive materials, highlighting their potential as stable mediator platforms for glucose biosensing.
