POS8-0524
DNA Rigidity-Dependent Force Transmission for Mechanophore Activation
Topic
S8. Frontiers of Functional Polymers in Biology and Medicine
When and Where
Oct 1, 2026
08:30 - 09:30
Room 301 (Grand Ballroom)
Session Chairs
Jinkee HONG
Ki Su KIM
Presenter(s)
minjeong Ku (Pukyong National University)
Co-Author(s)
Abstract
Mechanophores (MPs) are typically embedded in synthetic polymers to enable force-mediated chemical transformations. Previous studies investigated ultrasonic mechanophore scission using dsDNA–MP–dsDNA architectures with varying DNA lengths and mechanophore types, demonstrating rapid reactions and compatibility with high-throughput gel electrophoresis analysis. In this study, we compared the ultrasonic scission behavior of dsDNA–MP–dsDNA and ssDNA–MP–ssDNA architectures with identical lengths and mechanophores to investigate the effect of DNA strand structure on force transmission efficiency. Time-dependent ultrasonic cleavage was analyzed using gel electrophoresis and capillary electrophoresis.distinct scission kinetics were observed between double-stranded and single-stranded DNA systems, indicating that DNA structural rigidity and conformation influence mechanophore activation under ultrasonic conditions
