ORGS1-0481
Red-Light-Absorbing Donor–Acceptor Conjugated Polymer Nanoparticles Enable Efficient and Biocompatible Photobiocatalysis
Topic
GS1. Graduate Student Oral Session I: Colloidal and Interfacial Polymer Science
When and Where
Sep 28, 2026
15:00 - 15:12
Room 101
Session Chairs
Yoon-Ho HWANG
Jang-Hwan KIM
Hyosung AN
Presenter(s)
Huan Dang (Max Planck Institute for Polymer Research)
Co-Author(s)
Abstract
Redox enzymes offer high selectivity in chemical transformations, but their practical applications require continuous regeneration of expensive and unstable redox cofactors. Photocatalytic cofactor regeneration has shown promise as an efficient and sustainable strategy. However, most reported systems rely on ultraviolet or blue-light excitation, frequently leading to photodamage and enzyme deactivation. Here, we present a red-light-driven photobiocatalytic platform based on well-dispersible nanoparticles of indacenodithiophene–co–benzothiadiazole (IDTBT), a conjugated polymer known for its strong red-light absorption and favorable optoelectronic properties. By employing non-ionic surfactants, IDTBT nanoparticles remain colloidally stable in enzyme-compatible aqueous buffers, enabling their application in photobiocatalysis. Under red-light irradiation, these nanoparticles efficiently catalyze the oxidation of NADH and FADH2, while significantly improving enzyme activity compared to conventional blue-light systems. To further suppress enzyme deactivation caused by reactive oxygen species (ROS), we implement a dual protection strategy combining silica encapsulation and catalase, effectively protecting enzymes against short- and long-lived ROS over multiple catalytic cycles. These results highlight IDTBT-based red-light-driven photocatalysis as an efficient and enzyme-compatible strategy for sustained cofactor regeneration under mild aqueous conditions
