POS4-0374
Bio‐Templated Chiral Metal-Organic Framework for Enantioselective Chemoresistive Sensing
Topic
S4. Colloids, Interfaces, and Molecular Assemblies for Functional Soft Materials
When and Where
Sep 30, 2026
08:30 - 09:30
Room 301 (Grand Ballroom)
Session Chairs
Heesuk KIM
Jinhye BAE
Presenter(s)
Minkyu Kim (Dankook University)
Co-Author(s)
Abstract
Chiral metal-organic frameworks (MOFs) have gained rising attention as highly organized and porous chiral materials for diverse applications, such as chiral catalysis and enantiomer separation. Traditionally, the synthesis of chiral MOFs has involved complex pathways that rely on a narrow selection of organic chiral ligands. In this study, we introduce a template-directed approach to synthesize a chiral MOF using purely achiral building blocks. By guiding the assembly of standard precursors within nanostructured bundles of a chiral nematic cellulose nanocrystal template, we successfully synthesized a chiral zeolitic imidazolate framework (ZIF). Unlike conventional freely grown ZIF-8, which typically forms a cubic crystal structure with the I-43 m space group, this bio-templated ZIF adopts a distinct tetragonal structure belonging to the chiral P41 space group. Next, we investigated the possibility of using this chiral MOF as a chemoresistive enantioselective sensor for differentiating enantiomers. The results revealed that the chiral ZIF is highly effective for enantioselective chemoresistive sensing. Specifically, it exhibits an overall limit of detection (LOD) of 39 μM and a limit of chiral detection (LOCD) of 300 μM for the chiral amino acids, D- and L-alanine.
