POS8-0346
Fabrication of ChS-APBA/EGCG Functionalized Biodegradable PHB/PEO Ultrafine Fiber Sheets for Wound Healing
When and Where
Nov 30, -0001
12:00am - 12:00am
Presenter(s)
Nayoung Park (금오공대)
Co-Author(s)
Abstract
Biodegradable wound dressings with tissue adhesiveness and bioactive functions are promising materials for effective wound healing. Polyhydroxybutyrate/poly(ethylene oxide) (PHB/PEO) ultrafine fiber sheets were fabricated by electrospinning and functionalized with chondroitin sulfate-(3-aminomethyl phenyl) boronic acid/epigallocatechin-3-gallate (ChS-APBA/EGCG). ChS-APBA was synthesized via an EDC/NHS reaction, and EGCG was conjugated through dynamic covalent bonding between boronic acid and diol groups. The successful synthesis and surface modification were confirmed by FT-IR, 1H NMR, UV-Vis, FE-SEM, and EDS analyses. The optimized PHB/PEO ratio was 8:2, and the coated fiber sheets exhibited improved hydrophilicity, tissue adhesion, antioxidant activity, and biocompatibility. In vivo wound healing tests demonstrated enhanced wound closure and tissue regeneration compared with gauze and Tegaderm™. These results suggest that ChS-APBA/EGCG-functionalized PHB/PEO ultrafine fiber sheets have potential as functional wound dressings..
