Controlled C–N Bond Construction in Polymers via Post-Polymerization Amidation Strategies

Post-polymerization modification (PPM) offers a versatile platform for introducing chemical functionality into established polymer architectures, providing opportunities to tailor polymer properties beyond the structural constraints of conventional polymer synthesis. However, achieving efficient functionalization while maintaining the structural integrity and molecular characteristics of the parent polymer remains a fundamental challenge.

Herein, we investigate amidation-based strategies for the controlled construction of C–N bonds in diverse polymer architectures. By exploiting complementary chemical reactivities of polymer backbones and functional groups, selective incorporation of amide functionalities can be achieved under mild reaction conditions. The developed approaches enable molecular-level modification of polymers while minimizing undesired structural changes, providing access to functionalized materials with tunable chemical and physical properties.