KEIDS5-1675
The Power of Helicity Memory for Helical Polymer Synthesis and Applications
Topic
IDS5. Frontiers in Advanced Polymeric Materials (Sponsored by Toray Science Foundation)
When and Where
Sep 29, 2026
16:30 - 16:55
Room 105
Session Chairs
Kang Hee Ku
Presenter(s)
Eiji Yashima (National Tsing Hua University)
Co-Author(s)
Abstract
The helix is a prevalent structural motif in nature, especially among biological polymers that perform sophisticated functions. In polymer and supramolecular chemistry, controlling helicity and its handedness is an attractive challenge due to its potential applications in chiral materials. Previously, we reported a series of unique macromolecules that fold into either a right- or left-handed helical conformation via noncovalent interactions. These macromolecules exhibit dynamic or static memory of the induced helicity [1, 2]. In this study, we present the synthesis and applications of poly(biphenylylacetylene)s (PBPA) with static helicity memory. These polymers function as switchable chiral materials for enantiomer separation, serving as chiral stationary phases (CSPs) in high-performance liquid chromatography (HPLC), as well as for chiral sensing and asymmetric catalysis [3]. Additionally, I will discuss a recently discovered "self-learning enantioseparation" system based on ultrafast helix induction and its subsequent static memory [4].
References
[1] Yashima E.; Ikai T.; Maeda K. et al., Chem. Rev. 2016, 116, 13752-13990.
[2] Maeda K.; Yashima E. et al., J. Am. Chem. Soc. 2020, 142, 7668-7682; Sci. Adv. 2021, 7, eabg5381.
[3] Ikai T.; Yashima E. et al., Angew. Chem., Int. Ed. 2024, 63, e202412752; Angew. Chem., Int. Ed. 2024, 63, e202318712. Maeda K.; Yashima E. et al., Angew. Chem., Int. Ed. 2023, 62, e202217020. Ikai T.; Yashima E. et al., Angew. Chem., Int. Ed. 2023, 62, e202301127. Ikai T.; Yashima E. et al., Angew. Chem., Int. Ed. 2023, 62, e202306252. Ikai T.; Yashima E. et al., J. Am. Chem. Soc. 2023, 145, 24862- 24876.
[4] Ikai T.; Yashima E. et al., J. Am. Chem. Soc. 2026, 145, 16776–16787.
References
[1] Yashima E.; Ikai T.; Maeda K. et al., Chem. Rev. 2016, 116, 13752-13990.
[2] Maeda K.; Yashima E. et al., J. Am. Chem. Soc. 2020, 142, 7668-7682; Sci. Adv. 2021, 7, eabg5381.
[3] Ikai T.; Yashima E. et al., Angew. Chem., Int. Ed. 2024, 63, e202412752; Angew. Chem., Int. Ed. 2024, 63, e202318712. Maeda K.; Yashima E. et al., Angew. Chem., Int. Ed. 2023, 62, e202217020. Ikai T.; Yashima E. et al., Angew. Chem., Int. Ed. 2023, 62, e202301127. Ikai T.; Yashima E. et al., Angew. Chem., Int. Ed. 2023, 62, e202306252. Ikai T.; Yashima E. et al., J. Am. Chem. Soc. 2023, 145, 24862- 24876.
[4] Ikai T.; Yashima E. et al., J. Am. Chem. Soc. 2026, 145, 16776–16787.
