POS8-0100
Synthesis of Rice Straw Dialdehyde Cellulose and Its Application in Hydrogels
Topic
S8. Frontiers of Functional Polymers in Biology and Medicine
When and Where
Oct 1, 2026
08:30 - 09:30
Room 301 (Grand Ballroom)
Session Chairs
Jinkee HONG
Ki Su KIM
Presenter(s)
Kritsana Ruenjai (Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University)
Co-Author(s)
Abstract
Rice straw dialdehyde cellulose (RDAC) is a biocompatible, biodegradable, and low-toxicity cellulose derivative containing reactive aldehyde groups, synthesized via periodate oxidation. To enhance RDAC synthesis, various concentrations of sodium chloride (NaCl) were introduced during periodate oxidation. RDAC was characterized by aldehyde content and FTIR. The aldehyde content of NaCl-assisted RDAC was higher than the control. Moreover, FTIR results revealed a reduction in hydrogen bonds of NaCl-assisted RDAC, indicating that the addition of NaCl improved the periodate oxidation efficiency. The optimized RDAC was subsequently used as a natural crosslinking agent to fabricate polyvinyl alcohol (PVA)/chitosan (Chi) hydrogels. Formulations were prepared by varying chitosan (0.375% and 0.5% w/v) and RDAC (0.25%, 0.5%, and 1.0% w/v) concentrations. FTIR confirmed successful dual-network formation via Schiff base linkages with chitosan and hemiacetal bonds with PVA. The Chi-0.5/RDAC-0.25 hydrogel reached the highest swelling index of 2.45 and elongation at break of 53.223 ± 2.854%. However, the integrity value of the Chi-0.5/RDAC-0.25 formulation was the lowest (61.12%), which corresponded to poor mechanical properties, exhibiting the lowest puncture strength (0.449 ± 0.020 N/mm2) and Young’s modulus (0.191 ± 0.028 N/mm2). Conversely, the Chi-0.375/RDAC-1.0 hydrogel showed the lowest swelling index of 0.66 and elongation at break of 30.762 ± 0.335% but had the highest integrity value (76.57%) with the highest puncture strength (2.467 ± 0.047 N/mm2) and Young’s modulus (2.428 ± 0.083 N/mm2). These findings suggested that the physical and mechanical properties of dual-network PVA/chitosan hydrogels could be tailored by adjusting the ratios of RDAC and chitosan, showing strong potential for further development in wound dressing applications.
