POS8-1585
SWELLING BEHAVIOUR AND PHENOLIC RELEASE FROM BUCCAL FILMS BASED ON BIODEGRADABLE POLYMERS AND ACEROLA BY-PRODUCTS EXTRACT
Topic
S8. Frontiers of Functional Polymers in Biology and Medicine
When and Where
Sep 30, 2026
08:30 - 09:30
Room 301 (Grand Ballroom)
Session Chairs
Heesuk KIM
Jinhye BAE
Presenter(s)
Leticia Carvalho (University of São Paulo)
Co-Author(s)
Abstract
Acerola by-products were valorized by ultrasound-assisted extraction using water and ethanol for 5–20 min. The optimal extraction condition was selected based on total phenolic content (TPC) and antioxidant activity. The 5-min hydroethanolic (40% (v/v) ethanol) extract presented 2.28 ± 0.33 mg GAE/mL, 4.84 ± 0.45 μmol Trolox equivalents/mL by ABTS, and 49.12 ± 10.49 μmol FeSO₄ equivalents/mL by FRAP. After ethanol removal, the extract used for film preparation exhibited a concentrated TPC of 5.11 ± 0.39 mg GAE/mL. Buccal films were produced by mixing the extract with 2% (w/w) polymer solutions of chitosan, hydroxypropyl methylcellulose (HPMC), pectin, or sodium hyaluronate at a 1:1 (w/w) ratio. Swelling and phenolic release were evaluated in phosphate-buffered saline (pH 6.8) to simulate buccal cavity conditions. Polymer composition strongly influenced film hydration and release behavior. Hyaluronate and pectin films hydrated rapidly and partially dissolved after approximately 1 h, whereas chitosan and HPMC films swelled, forming hydrated gel-like matrices that maintained structural integrity throughout the assay. These findings suggest that polymer ionization and intermolecular interactions under simulated buccal pH may contribute to matrix hydration and phenolic diffusion, providing design principles for sustainable biodegradable films with tailored buccal bioactive delivery.
