POS8-1468
Novel Liquid Embolic Compositions with Inherent Radiopacity for Endovascular Embolization with Iodinated Cyanoacrylate Structure
Topic
S8. Frontiers of Functional Polymers in Biology and Medicine
When and Where
Oct 1, 2026
08:30 - 09:30
Room 301 (Grand Ballroom)
Session Chairs
Jinkee HONG
Ki Su KIM
Presenter(s)
Subin Park (Seoul National University)
Co-Author(s)
Abstract
Liquid embolic agents have been widely used for endovascular embolization because of their permanent occlusive capability, excellent injectability, and efficient vascular filling. However, Histoacryl®, one of the most commonly used liquid embolic agents, has inherent limitations, including the absence of intrinsic radiopacity and strong adhesion to microcatheters, which hinder procedural control and increase the risk of catheter entrapment.
To address these limitations, a novel liquid embolic formulation based on iodinated and fluorinated cyanoacrylates was developed. The iodinated monomer, 2-iodoethyl 2-cyanoacrylate (IECA), provides an iodine content of 1,100 mg I/mL, which is substantially higher than that of Lipiodol® (480 mg I/mL), enabling excellent intrinsic radiopacity for real-time fluoroscopic visualization. The fluorinated monomer, 2,2,3,3,3-pentafluoropropyl 2-cyanoacrylate (PFPCA), exhibited rapid polymerization (15.77 ± 1.96 μL/s) owing to the strong electron-withdrawing effect of its pentafluoropropyl group and effectively compensated for the relatively slow polymerization of IECA, even at low incorporation ratios.
Furthermore, the high hydrophobicity of PFPCA significantly reduced the microcatheter adhesion force to 8.65 ± 0.79 N compared with 11.51 ± 0.45 N for Histoacryl®, thereby improving catheter retrievability and procedural safety. In vivo embolization of rabbit renal arteries using the optimized formulation of IECA, PFPCA, and ethyl oleate achieved complete and stable occlusion of the target vessels.
Overall, the proposed iodinated and fluorinated cyanoacrylate formulation provides enhanced radiopacity, controllable polymerization behavior, and reduced catheter adhesion. These improvements demonstrate its potential as a next-generation liquid embolic agent with improved procedural control and reduced complication risk during endovascular embolization.
To address these limitations, a novel liquid embolic formulation based on iodinated and fluorinated cyanoacrylates was developed. The iodinated monomer, 2-iodoethyl 2-cyanoacrylate (IECA), provides an iodine content of 1,100 mg I/mL, which is substantially higher than that of Lipiodol® (480 mg I/mL), enabling excellent intrinsic radiopacity for real-time fluoroscopic visualization. The fluorinated monomer, 2,2,3,3,3-pentafluoropropyl 2-cyanoacrylate (PFPCA), exhibited rapid polymerization (15.77 ± 1.96 μL/s) owing to the strong electron-withdrawing effect of its pentafluoropropyl group and effectively compensated for the relatively slow polymerization of IECA, even at low incorporation ratios.
Furthermore, the high hydrophobicity of PFPCA significantly reduced the microcatheter adhesion force to 8.65 ± 0.79 N compared with 11.51 ± 0.45 N for Histoacryl®, thereby improving catheter retrievability and procedural safety. In vivo embolization of rabbit renal arteries using the optimized formulation of IECA, PFPCA, and ethyl oleate achieved complete and stable occlusion of the target vessels.
Overall, the proposed iodinated and fluorinated cyanoacrylate formulation provides enhanced radiopacity, controllable polymerization behavior, and reduced catheter adhesion. These improvements demonstrate its potential as a next-generation liquid embolic agent with improved procedural control and reduced complication risk during endovascular embolization.
