POS4-1326
Light modulated kinetic control of covalent peptide assembly toward hierarchical hollow nanostructures
Topic
S4. Colloids, Interfaces, and Molecular Assemblies for Functional Soft Materials
When and Where
Sep 29, 2026
08:30 - 09:30
Room 301 (Grand Ballroom)
Session Chairs
Hae Jung SON
Boseok KANG
Presenter(s)
Yun-Mi Hur (kyungpook national university)
Co-Author(s)
Abstract
Supramolecular peptide assembly exploits dynamic noncovalent interactions to construct hierarchical nanostructures with diverse functions. However, intrinsically low energy barriers of noncovalent interactions makes peptide assembly highly susceptible to environmental fluctuations, where subtle changes in assembly conditions can dramatically alter assembly pathways and resulting architectures. Here, we introduce a light-modulated kinetic strategy for covalent peptide assembly that spatially regulates covalent-supramolecular gradients within peptide nanoparticles. Selective dissociation of the noncovalent compartments yielded hollow peptide nanostructures with precisely tunable particle size, shell thickness, and cavity dimensions. Furthermore, sequential light irradiation enabled orthogonal regulation of particle size and shell thickness, expanding the structural programmability. The resulting hollow peptide nanostructures served as versatile platforms for biomineralization, peptide co-assembly, enzyme immobilization, and hierarchical secondary assembly, yielding multifunctional nanoarchitectures with catalytic, photothermal, and biofunctional properties. These findings provide fundamental insights into kinetically controlled covalent peptide assembly and establish a versatile design strategy for engineering hierarchical peptide nanostructures with tunable structures and multifunctional capabilities.
[Reference]
Yun-Mi Hur, Kido Kwon, Kyoung-Ik Min, Light-Modulated Kinetic Control of Covalent-Supramolecular Gradients for the Assembly of Hollow Peptide Nanostructures, Adv. Compos. Hybrid Mater., 2026, 9, 134.
[Reference]
Yun-Mi Hur, Kido Kwon, Kyoung-Ik Min, Light-Modulated Kinetic Control of Covalent-Supramolecular Gradients for the Assembly of Hollow Peptide Nanostructures, Adv. Compos. Hybrid Mater., 2026, 9, 134.
