POS8-1299
Tailored Enzyme-Mimicking Diblock Polymer Brushes for Antifouling and NO-Mediated Antibacterial Interfaces
Topic
S8. Frontiers of Functional Polymers in Biology and Medicine
When and Where
Sep 30, 2026
08:30 - 09:30
Room 301 (Grand Ballroom)
Session Chairs
Heesuk KIM
Jinhye BAE
Presenter(s)
Seung Won Yang (Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST))
Co-Author(s)
Abstract
Zwitterionic polymer brushes are promising for biomedical surface modification due to their strong resistance to nonspecific biological adhesion. However, their limited antibacterial activity restricts their effectiveness against bacterial colonization and biofilm formation. To address this limitation, GPx-mimicking organoselenium moieties were incorporated into a polymer brush system to enable catalytic nitric oxide (NO) generation. In this study, a surface-segregating initiator (SSI) strategy combined with surface-initiated atom transfer radical polymerization (SI-ATRP) was used to fabricate diblock polymer brushes on polymeric substrates. The brushes consisted of a zwitterionic antifouling block and an NO-generating antibacterial block. By adjusting the block composition, antifouling and antibacterial performance were balanced. The optimized surface reduced protein adsorption, platelet adhesion, bacterial colonization, and biofilm formation, while attenuating host inflammatory responses in vivo.
