POS8-1292
Kaolin-containing Kombucha Nanocellulose Bioink for Repair of Complex Tissue Defects
Topic
S8. Frontiers of Functional Polymers in Biology and Medicine
When and Where
Oct 1, 2026
08:30 - 09:30
Room 301 (Grand Ballroom)
Session Chairs
Jinkee HONG
Ki Su KIM
Presenter(s)
Sunggeun Lee (Seoul National university of science and technology)
Co-Author(s)
Abstract
In situ bioprinting for complex tissue defects requires a bioink system capable of immediate deposition onto irregular surfaces while maintaining structural stability and cytocompatibility. This study presents a mobile twin-screw processing strategy using a kombucha SCOBY-derived nanocellulose/chitosan hydrogel reinforced with bioactive kaolin nanoparticles. The kaolin-reinforced bioink exhibited excellent shear-thinning behavior and significantly improved tensile, dynamic mechanical, and cyclic compression properties. These enhanced formulations supported the stable construction of self-standing, multilayered architectures, including tubular and defect-filling geometries. In vitro assays with MC3T3-E1 cells demonstrated high viability, uniform localization, and accelerated extracellular matrix activity. These findings indicate that mobile twin-screw processing successfully integrates bioink homogenization and direct deposition, offering a practical point-of-care approach for reconstructing irregular bone, cartilage, and soft tissue defects.
Acknowledgement: This work was financially supported by the Seoul National University of Science and Technology, Republic of Korea.
Acknowledgement: This work was financially supported by the Seoul National University of Science and Technology, Republic of Korea.
