POS8-1271
Glycocholic Acid-Chondroitin Sulfate Conjugates-Coated Solid Lipid Nanoparticles for Oral Metronomic Chemotherapy
Topic
S8. Frontiers of Functional Polymers in Biology and Medicine
When and Where
Sep 30, 2026
08:30 - 09:30
Room 301 (Grand Ballroom)
Session Chairs
Heesuk KIM
Jinhye BAE
Presenter(s)
Sujeong Han (The catholic university of Korea)
Co-Author(s)
Abstract
Lipid nanoparticles are utilized in the delivery of hydrophobic drugs, such as docetaxel (DTX), to enhance the oral bioavailability of pharmaceutical agents. In this study, we proposed the use of DTX-loaded solid lipid nanoparticles (DNP) coated with a glycocholic acid (GCA)-chondroitin sulfate (CS) conjugate. The carboxyl group of GCA was modified with ethylenediamine prior to its conjugation with CS. DNP-GS was formed by electrostatic interaction between cationic DNP and anionic GCA-CS conjugates. The plasma concentration of DTX was found to be longer-lasting after oral administration of DNP-GS compared to intravenous injection for 24 hours in C57BL/6 mice. Besides, the daily oral administration of DNP-GS showed dose-dependent effects in inhibiting tumor growth. Hematological and histological toxicity was not observed in the liver and major organs. Hence, oral administration of DNP-GS may serve as an alternative to intravenous injection given its favorable stability and ease of upkeep.
