POS4-1250
Conformable Ultrasound Patch with Suction-Cavitation Modality for Enhanced Needle-Free Transdermal Delivery
Topic
S4. Colloids, Interfaces, and Molecular Assemblies for Functional Soft Materials
When and Where
Sep 29, 2026
08:30 - 09:30
Room 301 (Grand Ballroom)
Session Chairs
Hae Jung SON
Boseok KANG
Presenter(s)
Chang Rok Park (Sungkyunkwan University)
Co-Author(s)
Abstract
Recent transdermal drug delivery systems have gained attention as strategies that minimize the risk of blood-borne infections, such as HIV and hepatitis B/C, while enabling the non-invasive delivery of protein-based macromolecular drugs requiring high biocompatibility and precise targeting across the stratum corneum. Here, we propose a non-invasive ultrasonic suction coupling (USC) system that induces negative pressure on the stratum corneum under a low preload (~15 kPa), thereby reducing its structural density and enabling the delivery of macromolecules via ultrasound along the resulting void pathways. In addition, the USC system can intrinsically load drugs within a hydrogel-based suction inducer and utilizes heat generated from the ultrasonic device to trigger a gel-sol transition, thereby establishing a leakage-free, sealed delivery structure. Using this sealed system, we demonstrate the stable delivery of ultra-large macromolecules, such as FITC-dextran (Mw > 150 kDa), to depths exceeding 500 µm. Furthermore, a 4-week human clinical study verified the skin recovery effect of PDRN-based drug delivery, showing reductions of approximately 80% in fine lines and 60% in deep wrinkles. This approach introduces a new direction for non-invasive macromolecular delivery, establishing a foundation for precise drug delivery and expanded clinical applications across biomedical fields.
