POS8-1220
Ultrasound-Activated MXene@MnO₂-Embedded Adhesive Hydrogel for Postoperative Skin Cancer Therapy
Topic
S8. Frontiers of Functional Polymers in Biology and Medicine
When and Where
Sep 30, 2026
08:30 - 09:30
Room 301 (Grand Ballroom)
Session Chairs
Heesuk KIM
Jinhye BAE
Presenter(s)
JUNHEE KIM (Pohang University of Science and Technology)
Co-Author(s)
Abstract
Incomplete tumor clearance and delayed wound repair remain coupled challenges in postoperative skin cancer therapy, as residual malignant cells at the resection margin can drive local recurrence while surgical excision generates irregular cutaneous defects that impair tissue reconstruction. These limitations highlight the need for a localized postoperative platform that can retain therapeutic activity within the resection bed while supporting wound repair. Here, we developed an ultrasound-activated adhesive hydrogel by embedding MXene@MnO₂ nanoheterostructures into a Gel-SH/HA-DOPA double-network matrix. The redox-active MnO₂ component serves as a metal oxide sonosensitizer, while its coupling with Ti₃C₂Tₓ MXene forms a heterointerface that facilitates ultrasound-induced charge separation and enhances reactive oxygen species generation. Ultrasound further enables noninvasive activation with improved tissue penetration and spatiotemporal control, suggesting applicability to postoperative lesions beyond superficial skin defects. The Gel-SH/HA-DOPA double network combines gelatin-derived bioactivity with catechol-mediated wet adhesion and thiol–catechol crosslinking, providing mechanical stability, conformal coverage of irregular wound surfaces, and local retention of the therapeutic nanoheterostructures. In addition, the hyaluronic acid component offers an extracellular matrix-mimetic microenvironment favorable for hydration, cell migration, and cutaneous repair. By integrating ultrasound-responsive tumor ablation with adhesive hydrogel-mediated wound management, this MXene@MnO₂-embedded hydrogel offers a localized strategy for postoperative recurrence suppression and skin regeneration.
