POS8-1169
A Molecularly Imprinted Hierarchical SnO2 Nanowire/Fe2O3 Nanoflake Photoelectrochemical Sensor for Selective Fibrinogen Detection under Visible-Light Illumination
Topic
S8. Frontiers of Functional Polymers in Biology and Medicine
When and Where
Oct 1, 2026
08:30 - 09:30
Room 301 (Grand Ballroom)
Session Chairs
Jinkee HONG
Ki Su KIM
Presenter(s)
Seok Jin Lim (Kyungpook National University)
Co-Author(s)
Abstract
A molecularly imprinted photoelectrochemical sensor based on a hierarchical fluorine-doped tin oxide (FTO)/SnO2 nanowire (NW)/Fe2O3 nanoflake (NF) photoelectrode was developed for sensitive and selective fibrinogen (Fib) detection under visible-light illumination. The hierarchical photoelectrode was designed to promote visible-light-driven charge generation, charge separation, and electron transport. High-aspect-ratio SnO2 NWs grown on FTO provided direct electron-transport pathways for charge collection, while Fe2O3 NFs acted as visible-light-active nanostructures that improved light harvesting and promoted charge separation within the SnO2 NW/Fe2O3 NF heterostructure. Prior to molecular imprinting, a thin polytyramine underlayer was electropolymerized to introduce amine-rich surface functionality. A scopoletin polymer film was then electropolymerized in the presence of Fib, followed by template removal to generate target-complementary recognition cavities. The morphology, crystallinity, and surface chemical states of the electrodes were investigated to verify the hierarchical heterostructure and imprinted polymer interface. Fib sensing was evaluated in human plasma by chronoamperometry under intermittent visible-light irradiation, and the sensor exhibited concentration-dependent photocurrent responses. Adsorption behavior was analyzed to evaluate binding kinetics and equilibration characteristics of the imprinted layer. Selectivity was assessed against bovine serum albumin, immunoglobulin G, hemoglobin, and myoglobin to confirm target-specific recognition in a biologically relevant matrix. Reproducibility, reusability, and long-term storage stability were examined to assess analytical reliability. These results demonstrate that coupling a SnO2 NW/Fe2O3 NF photoelectrode with a Fib-imprinted scopoletin interface provides an effective strategy for selective photoelectrochemical detection of Fib in complex biological samples.
