INS11-1015
Biopolymer-Encapsulated Plasmonic Nanoparticles: A Scalable Platform for Advanced Engineering Applications
Topic
S11. PMSE–PSK50 Anniversary Symposium: Advancing Polymer Science for a Sustainable and Intelligent Future
When and Where
Sep 30, 2026
15:00 - 15:25
Room 110
Session Chairs
Gregory PETERSON
Presenter(s)
Kyoungweon Park (AFRL/Aerovironment)
Co-Author(s)
Abstract
Due to their unique optoelectronic properties, plasmonic nanoparticles are prominent candidates for advanced biomedical and industrial applications, including sensing, imaging, catalysis, and cancer therapeutics. However, their susceptibility to irreversible aggregation and a lack of robust, cost-effective stabilization methods remain significant barriers to industrial deployment. Here, we present a highly scalable and cost-effective functionalization strategy for gold nanorods (AuNRs) using casein, an abundant, inexpensive, food-grade amphiphilic biopolymer. Compared to synthetic alternatives, casein provides a superior coating matrix due to its intrinsically disordered flexibility for optimal surface conformation, robust multivalent anchoring, and inherent biocompatibility. The resulting casein-functionalized AuNRs exhibit exceptional resilience against high ionic strength environments and extreme pH fluctuations. By integrating mixed casein proteins into a robust, protective hydrated shell around each nanorod, we achieved high-concentration, surfactant-free electrosteric stabilization. This biopolymer interface prevented aggregation, remaining well-dispersed while preserving its structural and optical integrity for over a year. To facilitate long-term storage, logistical efficiency, and seamless product integration, the liquid colloidal suspensions were converted into solid-phase powders via continuous, high-throughput spray-drying. Remarkably, the dry powders exhibit seamless, rapid redispersion in both polar and nonpolar solvents, fully retaining the nanorods' original aspect ratio and plasmonic properties. Finally, the shelf-stable Casein-AuNR powders were molded into functional 3D geometries. By enabling the long-term stabilization of anisotropic nanostructures in a scalable, solid format, this work bridges a critical gap between laboratory-scale synthesis and industrial application.
