POS8-0950
Thermal diffusion of alkyl derivatives of IR3535 in anisotropic hydroxypropyl cellulose films
Topic
S8. Frontiers of Functional Polymers in Biology and Medicine
When and Where
Oct 1, 2026
08:30 - 09:30
Room 301 (Grand Ballroom)
Session Chairs
Jinkee HONG
Ki Su KIM
Presenter(s)
Ekaterina Anosova (Disinfectology Institute of F.F. Erisman FSCH of Rospotrebnadzor)
Co-Author(s)
Abstract
Vector-borne diseases cause over 17% of all infectious diseases [1]. Among synthetic repellents, ethyl butylacetylaminopropionate (IR3535) is particularly notable. IR3535 is less toxic, making it suitable for vulnerable groups [2]. However, due to its high volatility, it is subject to rapid loss from the skin surface, which reduces the duration of its protective effect. One possible solution is to use polymeric carriers with controlled release. This study investigated the thermal diffusion of new alkyl derivatives of IR3535 in anisotropic hydroxypropyl cellulose films for the first time.
In order to study the influence of molecular structure on mass transfer, a homologous series of compounds with alkyl substituents of varying lengths – from methyl to hexyl – was synthesised. Their structure was confirmed using a combination of spectral and chromatographic mass spectrometry methods. The kinetics of mass transfer in the presence of a temperature gradient were studied. It was found that directed heat flow causes the controlled movement of repellent molecules towards the film surface. The matrix anisotropy and the length of the alkyl radical were found to have a significant effect on the thermal diffusion coefficient. Unlike concentration diffusion, thermal diffusion enables control of the distribution of the active ingredient using a single physical parameter: the temperature gradient. Creating a temperature gradient enables the release of the repellent towards the material surface, paving the way for prolonged and controlled release.
Thus, this study presents a novel formulation for the repellents controlled repellent release. The material suggested could be used for the creation of personal protective systems against blood-sucking arthropods.
References
1. Global public health intelligence report 2023. Geneva: WHO; 2024
2.Tavares M., et al. Trends in insect repellent formulations: A review. International Journal of Pharmaceutics. 2018; 539(1-2):190-209.
In order to study the influence of molecular structure on mass transfer, a homologous series of compounds with alkyl substituents of varying lengths – from methyl to hexyl – was synthesised. Their structure was confirmed using a combination of spectral and chromatographic mass spectrometry methods. The kinetics of mass transfer in the presence of a temperature gradient were studied. It was found that directed heat flow causes the controlled movement of repellent molecules towards the film surface. The matrix anisotropy and the length of the alkyl radical were found to have a significant effect on the thermal diffusion coefficient. Unlike concentration diffusion, thermal diffusion enables control of the distribution of the active ingredient using a single physical parameter: the temperature gradient. Creating a temperature gradient enables the release of the repellent towards the material surface, paving the way for prolonged and controlled release.
Thus, this study presents a novel formulation for the repellents controlled repellent release. The material suggested could be used for the creation of personal protective systems against blood-sucking arthropods.
References
1. Global public health intelligence report 2023. Geneva: WHO; 2024
2.Tavares M., et al. Trends in insect repellent formulations: A review. International Journal of Pharmaceutics. 2018; 539(1-2):190-209.
