Hydrogel Patches for Managing Inflammatory Skin Conditions
발표자
()
초록
내용
In conventional treatments for inflammatory skin diseases, corticosteroids are commonly prescribed to manage and control symptoms. However, long-term use of corticosteroids is associated with significant side effects, including Cushingoid changes, hyperglycemia, delayed wound healing, and skin thinning. Although nonsteroidal anti-inflammatory drugs have been introduced to mitigate these issues, they too carry risks, such as gastrointestinal, renal, and cardiovascular complications. Hydrogels, with their high water content, biocompatibility, and tunable physicochemical properties, have emerged as promising therapeutic biomaterials for delivery of small-molecule drugs, proteins, and cytokines. The hydrogel can also be engineered with multifunctional properties, such as adhesiveness, injectability, self-healing, and antibacterial capabilities. In this presentation, I will discuss our recent research on hydrogel patches designed to manage and control inflammatory skin conditions. By tuning their compositions and physicochemical characteristics, we have developed hydrogel patches that exhibit ROS-scavenging capability, controlled release of corticosteroids, and skin adhesiveness. Using animal models of atopic dermatitis and psoriasis, we demonstrate the potential of these hydrogel patches as effective therapeutic skin patches and cosmetic gels.