Korea-Italy Bilateral Symposium on Organic Bioelectronics: Organic Mixed Ionic-Electronic Conductors and Devices (English)
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Investigating Biorecognition Processes Using Label-free Biosensors Based on Electrolyte Gated Organic Transistors
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In the last decade, Electrolyte Gated Organic Transistors (EGOT) have gained increasing attention in the field of biosensing as very appealing alternatives to optical devices. Besides being analytical tools for healthcare applications, EGOT can also be used to investigate fundamental aspects of the biorecognition processes between two biomolecules. Both the thermodynamics and kinetics of interaction between biomolecules can be elucidated by applying appropriate binding models to analyze the device response. We will present some recent examples concerning the use of EGOT based biosensors for healthcare applications to sense nucleic acids, proteins, antibodies, which are biomarkers for a number of different pathologies, and will discuss how properties such as the gating voltage or the density of biorecognition units can impact on the binding process and therefore on the performance of EGOTs as biosensors.