Enhanced aqueous dispersibility of sulfasalazine and increased prodrug conversion rate by UV irradiation.
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Sulfasalazine is a pharmaceutical used to treat inflammatory diseases such as rheumatoid arthritis, ulcerative colitis, and Crohn's disease. However, sulfasalazine has poor solubility in water, and enhancing its solubility is crucial for efficient drug delivery. Previous studies have attempted to increase the solubility of sulfasalazine by attaching hydrophilic functional groups or utilizing specific nanostructures. However, these methods are difficult to use and take up a lot of time. Therefore, we aimed to investigate the increased solubility of sulfasalazine through photoisomerization induced by UV irradiation, leveraging the fact that sulfasalazine is a drug based on the azo-benzene structure. We also investigated whether the increased solubility has a positive impact on the degradation rate of the sulfasalazine drug through bacterial experiments.