Nanoengineering nucleic acid-based biopolymers for targeted cancer therapy
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초록
내용
Nucleic acid nanotechnology has recently been applied to package polymeric forms of functional DNA or RNA by rolling circle replication in various nanoplatforms for bioapplications. Although the physicochemical properties of nanoparticles are known key factors in systemic circulation and tumor-targeted delivery, elucidating the in vivo therapeutic effects of shape, size, and surface chemistry of polymeric nucleic acid nanoplatforms remains necessary. Here we introduce size-tunable, stimuli-responsive, and tumor-targetable nucleic acid nanocarriers by employing layer-by-layer (LBL) assembly for targeted anticancer drug delivery. These nano-formulations significantly enhance nucleic acid drug/carrier stability and plasma half-life during in vivo controlled biodistribution, ensuring effective delivery to targeted organs and cells with minimal cytotoxicity. Nucleic acid nanotechnology-based approaches offer promising novel therapeutic routes for cancer therapy and nanomedicine.