Specific scission of covalent bonds using mechanical force in DNA diblock architectures
발표자
()
초록
내용
An ultrasound-induced bond cleavage on mechanopore, a weak bond along the polymer chains, is one of the main foci of polymer mechanical chemistry. To date, there are not many studies on the role of polymers, which are mechanical force carriers. Here we report precisely prepared DNAs as the mechanocarriers (MCs) instead of conventional polymers for the mechanochemical bond scission. For this study, a DNA-linker-DNA structure was designed in which a linker is located at the center and two DNA MCs are connected to both termini. We mainly used polymerase chain reaction to engineer DNA MCs and ultrasound as the mechanical force. The effect of DNA MCs was evaluated by changing the length, rigidity, and shape of DNA segments. We investigated to precisely control the bond scission by external force transmitted to the linker through DNA MCs.