Cryo-3D printing for Hydrogel-based Porous Scaffold
발표자
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초록
내용
Pores play a crucial role in tissue engineering by facilitating the transport of essential substances to embedded cells. Despite significant progress in 3D bioprinting, achieving precise control over nanoscale pores remains a challenge. This study introduces a novel cryo-crosslinking method to create meso-macro porous structures within hydrogel scaffolds fabricated via 3D printing. Poly(ethylene glycol) diacrylate (PEGDA), known for its limited printability, is used as the primary ink, while Carbopol is employed as a rheology modifier to improve extrusion suitability. By adjusting the concentration of Carbopol, the properties of hydrogel-based bio-inks were successfully tailored for direct printing, leading to the formation of meso-macro scale porosity through cryogenic cross-linking. The porous structures of the 3D-printed scaffolds offer promising potential for applications in drug delivery and cell culture.