Cytocompatibility of Human Dermal Fibroblasts within 3D Bioprinted Constructs Containing Carbon Nanofiber Nanoparticles
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초록
내용
Carbon-based nanomaterials are particularly noted for increasing electrical conductivity, osteoconductivity, and the mechanical and thermal properties. This study incorporated carbon nanofiber nanoparticles (CNF NPs) into methacrylated gelatin (GelMA) to evaluate their capability to promote cell growth and proliferation. In vitro tests with normal human dermal fibroblasts (nHDF) over 7 days showed that CNF NPs caused dose-dependent cytotoxicity, with significant effects observed in the highly concentrated bioink scaffolds. The findings suggest that CNF NPs, at the concentrations tested, can hinder the cell proliferation and may not be suitable for skin tissue regeneration.