Tissue-Adhesive Drug Delivery System for Drug-Induced Skin Regeneration
발표자
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초록
내용
In this study, we developed a tissue-adhesive drug delivery system (DDS) for skin regeneration using the synergistic effects of the PHD inhibitor 1,4-dihydrophenonthrolin-4-one-3-carboxylic acid (1,4-DPCA) and the catechol functional group. Our DDS self-assembles into nanostructures through weak non-covalent and ionic interactions between 1,4-DPCA units. Alginate was functionalized with 1,4-DPCA and further conjugated with catechol groups via an EDC/NHS reaction. Spectroscopic analysis confirmed the synthesis, and the degree of substitution (DOS) was calculated. Fluorescence microscopy and SPR analysis validated the tissue adhesive properties, while in vitro tests demonstrated biocompatibility. This DDS shows potential for applications in artificial scar regeneration and tissue-like structures.