Korea-Italy Bilateral Symposium on Organic Bioelectronics: Organic Mixed Ionic-Electronic Conductors and Devices (English)
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Bio-hybrid Photoactive Interfaces for Optoelectronic Modulation of Living Cell Fate
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Use of light for selective and spatio-temporally resolved control of cell functions is emerging as a valuable alternative to electrical and chemical methods. Here, we propose the use of organic semiconductors as efficient and biocompatible opto-electronic transducers in the field of regenerative medicine. Devices able to selectively and precisely modulate the fate of living cells, from adhesion to proliferation, from differentiation to specific function, will be presented. Examples of practical applications include optical modulation of the activity of both excitable and non-excitable cells, the control of essential cellular switches like transient receptor potential and mechanosensitive channels, and effective modulation of calcium signaling for control of cell metabolism. Considered study-cases represent, to the best of our knowledge, first reports on use of organic semiconductors for optoelectronic modulation of the cell fate, with disruptive perspectives in regenerative medicine.