Enhancement of Mechanical Strength and Osteoconductivity of Acrylic Bone Cement by Leveraging Hypo-crystalline PMMA Powder and Bioactive Glass 45S5
발표자
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초록
내용
Poly(methyl methacrylate) (PMMA), the mainstream substance used for commercial acrylic bone cement (ABC), possesses intrinsic characteristics such as biocompatibility, easy processability, and high mechanical strength. In this study, we replaced pristine PMMA powder with hypo-crystallized PMMA (hc-PMMA) powder and bioactive glass 45S5. The unique nanostructure and high modulus of hc-PMMA itself enhanced the compressional strength of the resulting bone cement. Due to the high surface area and internal strain formed by the crystallization process, the addition of hc-PMMA dramatically decreased the polymerization time without any additional catalyst. Finally, the resulting bone cement exhibited higher osteoconductivity than the pristine ABC composite, as confirmed by the simulated body fluid (SBF) test. Based on these results, bone cement incorporating hc-PMMA and bioactive glass 45S5 could be an optimal candidate for the long-term fixation of load-bearing implants.