Development of photoresponsive nanogels for enhanced cancer phototherapy
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초록
내용
Photodynamic therapy (PDT) have been developed rapidly as future directions in cancer therapy. However, PDT using upconversion nanoparticles (UCNPs) still have concerns about their transformations and potential toxicity under physiological conditions. In this work, we develop UCNPs encapsulated nanogels as efficient carriers which is internalized by the cancer cells, thereby minimizing hazardous side effects. Nanogels are synthesized by Cu-free click chemistry between methyltetrazine (Tz) and trans-cyclooctene (TCO). They are successfully characterized by transmission electron microscopy and dynamic light scattering to investigate the size and shape of them. Moreover, the photoluminescence emission spectra are obtained under 808 nm laser excitation. In addition, 808 nm laser irradiation decrease the viability of HeLa cells, which is shown to be capable of therapeutic effects. Taken together, nanogels encapsulating UCNPs can have potential as a biomedical application for various types of diseases.