Controlled Chain Folding of Precise Poly(l-lactic acid) and Their Sequence-Specific Degradation
발표자
()
초록
내용
We first designed the sequence-defined PLLA derivatives which have "breaking points" at specifically defined intervals of LLA units to accelerate degradation with retained physical properties. Intentionally inducing folding in polymers at specific intervals enables them to maintain favorable properties without disrupting crystallite formation. We envisioned that implementing 1,3-diispropylcarbodiimide (DIC)-mediated step-growth polymerization introduce breaking points along the PLLA backbone at specific intervals of LLA units. Positioned at the apex of the PLLA crystal, the breaking point is designed not to interfere with crystallite formation, thus preserving the polymer's physical properties. Upon exposure to certain conditions, leading to depolymerization and accelerated environmental degradation. This approach offers a controlled and selective means to trigger degradation in high molecular-weight polymers while maintaining their characteristics.