A Mechanically Resilient and Tissue-conformable Real-time monitoring Hydrogel with Hemostatic and Antibacterial Capabilities for Wound Care
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Hydrogels have been used in wound dressings because of their tissue-like softness and biocompatibility. Here, we introduced tannic acid (TA) into a double network (DN) hydrogel consisting of poly(vinyl alcohol) (PVA) and poly(acrylic acid) (PAA) to realize a tough, self-healable, nonswellable, conformally tissue-adhesive, hemostatic, and antibacterial hydrogel. The TA within the DN hydrogel forms a dynamic network, enabling rapid self-healing (within 5 min) and offering effective energy dissipation for toughness and viscoelasticity. Interestingly, the TA also can serve as an effective hemostatic (blood-clotting index of 58.40 ± 1.5) and antibacterial component, which are required for a successful wound dressing. The hydrogel developed in this study enables rapid coagulation (within 10 sec) upon application to the wound site. Additionally, we plan to integrate IC circuit onto the hydrogel surface for real-time monitoring of bleeding.