Polyvinylpyrrolidone-Functionalized High-Z Inorganic Nanoparticles for Enhanced Cancer Radiotherapy
발표자
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초록
내용
Radiotherapy (RT) is a well-established cancer treatment, but its efficacy is often limited by damage to healthy tissue. This study investigates the potential of high atomic number (high-Z) nanoparticles as radiosensitizers to enhance RT effectiveness. We synthesized nanoparticles incorporating gold, gadolinium, and hafnium, and functionalized them with polyvinylpyrrolidone to improve biocompatibility and water dispersibility. These high-Z nanomaterials concentrate radiation, amplifying reactive oxygen species (ROS) production, modulating the cell cycle, and impeding DNA repair, ultimately triggering cancer cell death. Upon irradiation, each nanoparticle type demonstrated increased ROS generation and superior cancer cell cytotoxicity compared to controls. We also confirmed their X-ray imaging capability, suggesting potential for image-guided radiotherapy. This research contributes to developing more effective and targeted RT approaches, potentially improving treatment outcomes while reducing side effects.