Adhesive Hyaluronic Acid/Gelatin Hydrogels as Wound Dressings
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초록
내용
Skin damage often leads to chronic wounds, exacerbated by excessive reactive ROS and poor bleeding control. We propose natural polymer-based hydrogel dressings to address these issues. Hyaluronic acid (HA) was modified with 3-amino-1,2-propanediol and then oxidized to introduce aldehyde groups. This aldehyde HA was mixed with adipic acid dihydrazide-modified HA to form hydrogels. Gelatin was added during the gel formation, and the resultant gels were coated with gallic acid. Various properties of the hydrogels, including viscoelasticity, adhesion, and hemostasis, were evaluated in vitro. Gelatin increased the gel stiffness, while gallic acid improved adhesion capability of the gels. These hydrogels also exhibited excellent self-healing property, 3D printability, and stretchability. In animal studies, these gels efficiently suppressed ROS and promoted hemostasis, leading to faster healing. These hydrogels may be a solution for wound management, effectively controlling ROS and bleeding.