Upconversion nanoparticle-based multifunctional nanocomposites for photodynamic/chemodynamic/starvation synergistic cancer therapy
발표자
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초록
내용
Recently, strategies of multi-modal cancer therapy have sparked increasing interest in overcoming the intrinsic limitations of monotherapies and improving anticancer efficacy owing to its high efficacy, low toxicity, and low dosage. Upconversion nanoparticles (UCNPs) capable of converting near-infrared excitation into UV or visible emissions are an emerging class of luminescent nanomaterials with advantages compared to conventional fluorophores including low autofluorescence, high photostability, high signal-to-noise ratio, and no photobleaching. In this work, rare-earth-doped upconversion nanoparticles with a multi-shell structure were synthesized for multi-modal combination cancer therapy of photodynamic/chemodynamic/starvation therapy. In vitro studies demonstrated their physicochemical properties and synergistic anticancer effects.