Fabrication and Evaluation of a Powder-type Anti-adhesion Agent with Improved Tissue Adhesiveness using Modified Starch
발표자
()
초록
내용
Tissue adhesion is a phenomenon in which tissues and organs adhere to each other due to the formation of excessive fibrous tissue. To prevent adhesions, it is necessary to develop anti-adhesion agents that separate the injured area of the organ. In this study, a powder-type anti-adhesion agent was fabricated using dialdehyde starch (DAS) and poly(vinylpyrrolidone) (PVP). DAS was synthesized using an oxidizing agent to provide adhesive properties. DAS was cross-linked using glyoxal, and PVP was used to improve tissue adhesion. As a result, x-DAS/PVP(7:3) powder showed the highest tissue adhesion property. The x-DAS/PVP powder degraded in 7 days, and in vitro cytotoxicity experiments demonstrated the biocompatibility of the powder. From the in vivo animal test, post-operative tissue adhesion was completely reduced by applying a powder-type anti-adhesion agent. x-DAS/PVP powder-type anti-adhesion agent is suitable for application in laparoscopic surgery as well as open surgery.