Fabrication and characterization of biocompatible and biodegradable l-lysine polyurethane (LPU) nanoparticles for drug delivery system
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초록
내용
To obtain biodegradable biomaterial for matrix of drug delivery, L-lysine polyurethane (LPU) was designed using the biodegradable triblock oligomer polylactide-poly(ethylene glycol)-polylactide (PLA-PEG-PLA) as a soft segment, 1,6-hexamethylene diisocyanate (HMDI) as a hard segment and L-lysine ethyl ester (LEE) as a chain extender. PLA-PEG-PLA was synthesized by ring opening polymerization (ROP) of lactide monomer onto poly(ethylene glycol) core and stannous octoate as a catalyst. LEE was synthesized by esterification of L-lysine with ethanol using thionyl chloride as a catalyst. LPU nanoparticles were fabricated by using water-in-oil-in-water double emulsion technique for encapsulating anticancer drugs such as 5-fluorouracil (5-FU). The structure and composition of all synthesized materials was confirmed by 1H-NMR, 13C-NMR, FT-IR spectroscopies, and the molecular weights of polyurethane and PLA-PEG-PLA triblock were characterized by GPC analysis.