Long-term Stable Antibacterial and Biocompatible Polymer Coating on Contact Lenses for the Prevention of Keratitis
발표자
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초록
내용
The increasing incidence of serious bacterial keratitis, often exacerbated by inadequate contact lens (CL) care, necessitates innovative protective technology. This study introduces a long-lasting antibacterial, non-cytotoxic, transparent nanocoating for CLs via a solvent-free polymer deposition method, aimed at preventing bacterial keratitis. The nanocoating comprises stacked polymer films, with poly(dimethylaminomethyl styrene-co-ethylene glycol dimethacrylate) (pDE) serving as a biocompatible, antibacterial layer atop poly(2,4,6,8-tetramethyl-2,4,6,8-tetravinylcyclotetrasiloxane) (pV4D4), an adhesion-promoting layer. The pD6E1-g-pV4D4 film shows non-cytotoxicity towards two human cell lines and broad-spectrum antibacterial activity of >99% against four representative bacteria. The film maintains antibacterial activity >96% against MRSA for 9 weeks in phosphate-buffered saline and demonstrates exceptional mechanical durability, retaining its antibacterial properties after 15 washing cycles.