Lipid-polymer hybrid nanoparticles for subcutaneous fat reduction
발표자
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초록
내용
Lipid-polymer hybrid nanoparticles are emerging as useful tools for therapeutic drug delivery and imaging applications. The lipid component in nanoparticles aims to enhance permeability, while the polymer controls drug release. Fatty acid (FA), known for its biological affinity, is often integrated into nanoparticles. In particular, FA is actively metabolized within adipocytes. We propose that hybrid nanoparticles capable of releasing carbon dioxide gas could be effective for localized fat reduction in vivo. Lipid-polymer hybrid nanoparticles improved intracellular delivery to adipocytes compared to other cells. These hybrid nanoparticles effectively reduced subcutaneous fat pads of mice fed a high-fat diet, as confirmed by fat pad weight measurement and histological analysis. This approach demonstrates the potential of multifunctional lipid-polymer hybrid nanoparticle systems for various therapeutic applications, including localized fat reduction.