Bioinspired Technique for Antibody Immobilization on Various Surfaces
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초록
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Biosensors are vital for disease diagnosis and therapeutic monitoring, but many struggle with effectively immobilizing biological probes due to unsuitable chemical interactions. To solve this, we present a one-pot coating method inspired by marine organisms' adhesive mechanisms, utilizing the exceptional properties of polydopamine. Known for its hydrophilicity and versatile affinity for various substrates, polydopamine acts as a robust adhesive polymer, enhancing the attachment of neutravidin to sensor surfaces. This improves antibody immobilization through strong avidin-biotin interactions, leading to a significant increase in detection sensitivity. Validation with model biomarkers showed more than a tenfold improvement in sensitivity compared to commercial immuno-plates. This approach highlights the transformative potential of polydopamine in biosensor technology, offering a straightforward and effective solution to enhance biosensor performance in diverse biological applications.