POx-b-PCL Amphiphilic Copolymers for Nanoemulsion Stabilization and Enhanced Transdermal Drug Delivery
발표자
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초록
내용
We introduce poly(2-ethyl-2-oxazoline-b-ε-caprolactone) (POx-b-PCL), an amphiphilic polymeric emulsifier for nanoemulsion stabilization. POx-b-PCL's amphiphilicity was controlled by growing PCL chains from POx end groups via ring-opening polymerization. Self-assembly properties were confirmed through critical micelle concentration measurements and micellization observations. We optimized PCL chain length and POx-b-PCL concentration for surfactant efficacy using emulsion size and stability assessments. The resulting nanoemulsions showed enhanced transdermal delivery performance. This study demonstrates the potential of POx-b-PCL-stabilized nanoemulsions in advancing transdermal delivery systems, capitalizing on poly(2-ethyl-2-oxazoline)'s biocompatibility and hydrophilicity. Our findings suggest promising applications for this novel amphiphilic block copolymer in drug delivery.