Tissue-Targeted Drug Delivery System for Osteoarthritis Therapy Using Curcumin-Loaded PLGA Nanoparticles Coated with Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells
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초록
내용
Recent research has focused extensively on nanocarrier drug delivery systems (DDS). Among these, polymer nanocarriers can enhance drug stability, improve solubility, and enable sustained release. We developed a drug delivery system using cell membrane nanovesicles derived from induced pluripotent stem cell-derived mesenchymal stem cells (iMSC-CM-NVs). The DDS offers enhanced drug stability, sustained release, and high biocompatibility. Additionally, we have modified these nanoparticles with the degenerative cartilage-targeting peptide. CM-Cur-PNPs significantly decreased pro-inflammatory markers and increased chondrogenic markers. They also reversed the inflammatory environment by downregulating M1 macrophage markers and upregulating M2 macrophage markers. CM-Cur-PNPs modified with the degenerative cartilage-targeting peptide (OA-CM-Cur-PNPs). The CMNVs-based DDS platform modified with a tissue-targeting peptide exhibits significant potential as a next-generation platform for treating OA and other diseases.