Double Emulsion Capsule-Embedded 3D Printed Spatiotemporal Drug Delivery System
발표자
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초록
내용
Double emulsion capsule (DEC) refers to the encapsulated particles or droplets that are formed using double emulsion techniques. DECs offer several advantages across various fields, such as protection of ingredients, targeted delivery, and minimized side effects. Despite these advantages, high passive leakage from DEC and precise DEC placement in three-dimensional (3D) space remain major challenges. Here, we present a 3D spatiotemporal drug delivery system with DEC that exhibits low passive leakage. Integrating gold nanorods, well-known photo-thermal agents, into the polymer shell of DEC densifies the shell through electrostatic interaction, significantly reducing unwanted leakage. DEC-embedded 3D structures are fabricated by precisely placing DECs using a hybrid additive manufacturing technique that combines 3D printing and pick-and-place systems. DECs in the 3D structures are selectively ruptured at the desired time by a near-infrared laser, enabling spatiotemporal drug delivery.