Fabrication and Evaluation of PLGA Nanofibrous Sheets with Improved Tissue-Adhesive Property to Prevent Lung Air Leakage
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초록
내용
Postoperative air leakage, causing pleural sinusitis and pneumonia is a common problem in thoracic surgery. Conventional methods such as sutures, and cyanoacrylate adhesives were toxic, and poor adhesion. In this study, a poly(lactic acid-co-glycolic acid) (PLGA)/poly(vinyl pyrrolidone) (PVP) nanofibrous sheet for preventing lung air leakage was fabricated. PLGA has superb biocompatibility, and a controllable biodegradation rate according to the ratio of the PLA and PGA. PVP was introduced to improve the adhesion. Nanofiber sheets have a large surface area and mechanical compatibility with soft tissues. The surface properties of the sheet were assessed by SEM. The degradation rate and physical properties in a similar environment in the body were evaluated using a UTM and in vitro biodegradation tests. Air leakage prevention capacity against rupture pressure, and tissue adhesion was confirmed through the burst pressure tests and rheometer. Fabricated sheets showed improved air leakage prevention and adhesion property.