Development of Injectable Gelatin/Oxidized Hyaluronic Acid Hydrogels with Improved Mechanical and Biocompatible Properties
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In situ-formed hydrogels are gaining attention as versatile biomaterials in the biomedical field due to their minimally invasive nature and ease of administration. This study developed novel hybrid hydrogels using gelatin and oxidized hyaluronic acid (OHA). Gelatin offers excellent biocompatibility and cell adhesion but has high solubility at body temperature, limiting its applications. To overcome this, hybrid hydrogels were created by crosslinking gelatin with OHA without additional crosslinking agents. The gelation properties were influenced by the degree of OHA oxidation and polymer concentration. Mechanical and physical properties, evaluated through amplitude sweep and compressive strength tests, improved with increased OHA oxidation. The hydrogels also demonstrated injectability and self-healing ability. Cytotoxicity evaluations showed high biocompatibility. These findings demonstrate the potential of Gel/OHA hydrogels as ECM-based injectable biomaterials for various biomedical applications.