Porcine Skin-Based Biodegradable Nanofibers composited with Cellulose Acetates
발표자
()
초록
내용
Porcine skin-derived dECM is eco-friendly and biodegradable but lacks strong mechanical and physical properties. In this study, biodegradable and mechanically enhanced dECM nanofibers were created using cellulose acetate (CA) via electrospinning. Freeze-dried dECM powder was dissolved in HFIP at various concentrations to produce fibers, with clear nanofibers forming at a concentration of 6 w/v%. However, these dECM nanofibers exhibited poor physical stability in moisture and weak mechanical properties, deforming easily at room temperature. To address this, dECM fibers were combined with CA, resulting in uniformly shaped fibers with reduced diameters as the CA content increased. Additionally, dECM fibers with CA were more moisture-resistant and less prone to deformation at room temperature. FT-IR and SEM analyses confirmed the successful fabrication of dECM/CA nanofibers. Biodegradability tests in an anaerobic environment showed that pure dECM nanofibers degraded quickly, but the degradation rate decreased with higher CA content.